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In the iconic film "Desperately Seeking Susan," Rosanna Arquette shines in her role as Roberta Glass, a bored housewife who becomes obsessed with the enigmatic Susan. Arquette's performance is a perfect balance of comedy and vulnerability as she navigates a world of mistaken identities and unexpected adventures. Her on-screen chemistry with Madonna adds to the film's charm and allure. With Arquette's magnetic presence and impeccable comedic timing, "Desperately Seeking Susan" is a must-watch for fans of '80s romantic comedies.